Thymoquinone treatment against acetaminophen-induced hepatotoxicity in rats
نویسندگان
چکیده
منابع مشابه
Acetaminophen-induced hepatotoxicity.
The analgesic acetaminophen causes a potentially fatal, hepatic centrilobular necrosis when taken in overdose. The initial phases of toxicity were described in Dr. Gillette's laboratory in the 1970s. These findings indicated that acetaminophen was metabolically activated by cytochrome P450 enzymes to a reactive metabolite that depleted glutathione (GSH) and covalently bound to protein. It was s...
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Understanding the mechanism of chemical toxicity, which is essential for cross-species and dose extrapolations, is a major challenge for toxicologists. Standard mechanistic studies in animals for examining the toxic and pathological changes associated with the chemical exposure have often been limited to the single end point or pathways. Toxicoproteomics represents a potential aid to the toxico...
متن کاملHepatoprotective and Antioxidant Effect of Pavonia Zeylanica against Acetaminophen Induced Hepatotoxicity in Rats
The objective of the study was to investigate the methanol extract of Pavonia zeylanica (MEPZ) against acetaminophen induced hepatotoxicity and antioxidant activity in Wistar albino rats.The methanol extract of pavonia zeylanica (200, and 400 mg/kg body weight) was administered orally to two groups of rats (six animals per group) in order to evaluate the protective effect of the extract in rats...
متن کاملHepatoprotective Potential of Prosopis farcta Beans Extracts against Acetaminophen-induced Hepatotoxicity in Wister Rats
BACKGROUND Hepatotoxicity by acetaminophen is the most frequent cause of acute liver failure in many countries. Prosopis farcta beans extract (PFE) has some antioxidant property and may alleviate hepatotoxicity. Therefore, the aim of this study was to evaluate effects of PFE against acetaminophen-induced hepatotoxicity. METHODS Thirty-six male Wistar albino rats weighing 220 ± 30 g were distr...
متن کاملUse of Arctium lappa Extract Against Acetaminophen-Induced Hepatotoxicity in Rats
BACKGROUND Severe destructive hepatic injuries can be induced by acetaminophen overdose and may lead to acute hepatic failure. OBJECTIVE To investigate the ameliorative effects of Arctium lappa root extract on acetaminophen-induced hepatotoxicity. METHODS Rats were divided into 4 groups: normal control group, Arctium lappa extract group, acetaminophen-injected group, and acetaminophen treat...
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ژورنال
عنوان ژورنال: International Journal of Surgery
سال: 2014
ISSN: 1743-9191
DOI: 10.1016/j.ijsu.2013.12.013